This study assesses the fluidized bed granulation process for the optimization of a model formulation using in-line near-infrared (NIR) spectroscopy for moisture determination. NIR moisture measurement combined with temperature and humidity measurements provides a tool for the control of water during fluid bed granulation. In the pharmaceutical industry, fluid bed granulation processes require tight control to ensure reliability. Process control and end-point determination of a fluid bed granulation by application of near infra-red spectroscopy.
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