Describes how the lactoferrin test is used, when a lactoferrin test is ordered, and what the results of a lactoferrin test might mean. Also known as: Fecal Lactoferrin; Stool Lactoferrin; Fecal WBC Non-microscopic. Lactoferrin is a protein found in activated neutrophils a type of white blood cell. When the intestines are inflamed, activated neutrophils are shed into the stool. Leukocyte-derived lactoferrin is resistant to proteolysis and freeze thaw cycles. Clinical studies have shown that fecal lactoferrin levels of healthy persons (1.6 g/ml) are similar to IBS patients (1.
Lactoferrin is a marker for fecal leukocytes and a positive result is an indicator of intestinal inflammation. This elevation may be caused by acute infectious colitis or active inflammatory bowel disease (IBD). (Min: 1 g) Also acceptable: Place 5 g stool in enteric transport media (Cary-Blair) (ARUP Supply 29799). Fecal Lactoferrin; Fecal Leukocytes; Fecal WBC Non-microscopic; Stool Lactoferrin. Fecal leukocytes and fecal lactoferrin testing can provide more timely results and are therefore more useful in the ED setting than stool cultures in identifying causes of inflammatory diarrhea.
High lactoferrin levels are seen in people with inflammatory diseases ulcerative colitis or Crohn’s disease; low lactoferrin levels are seen in people with noninflammatory irritable bowel syndrome (IBS). Acute diarrhea is defined as three or more stools per day of decreased form from the normal, lasting for less than 14 days. Stool evaluation for fecal leukocytes (or lactoferrin, a byproduct of white blood cells) is a useful initial test because it may support a diagnosis of inflammatory diarrhea. Fecal Lactoferrin is a marker of Inflammation and is secreted by Leukocytes invading the Gastrointestinal (GI) Tract Walls 5. Fecal Lactoferrin is used as a non-invasive test to differentiate between IBS and IBD.
Lactoferrin, Qualitative, Stool (10156)
False positive results are due to contamination of stool sample with urine or blood, or due to more than an hour passed between sample taking and testing. Lactoferrin is released from leukocytes and it can be detected in the stool in 5 minutes. The Leuko EZ Vue test detects elevated levels of lactoferrin released from fecal leukocytes as a marker of intestinal inflammation. This test may not be appropiate in an immunocompromised patient CPT code(s):. Fecal lactoferrin and calprotectin are highly sensitive and specific markers for detecting intestinal inflammation. In intestinal inflammation, leukocytes invade the mucosa, which results in an increase in the excretion of lactoferrin into the feces 5, 7.